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AGING AND FRAILTY IN SILICO: THE PROPAGATION OF LOCAL DAMAGE THROUGH COMPLEX NETWORKS

Background: The relationships between aging, frailty and mortality are well documented but remain mainly empirical. We present a dynamical network model that explains the patterns of mortality and frailty. Methods: We developed a computational model of human organism as a complex dynamical network o...

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Detalhes bibliográficos
Publicado no:Innov Aging
Main Authors: Mitnitski, A.B., Rutenberg, A.D., Farrell, S., Rockwood, K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6184480/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igx004.3220
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