Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial

Background: Tuberculosis kills more people than any other bacterial infection worldwide. In tuberculous meningitis (TBM), a common functional promoter variant (C/T transition) in the gene encoding leukotriene A4 hydrolase (LTA4H), predicts pre-treatment inflammatory phenotype and response to dexamet...

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Vydáno v:Wellcome Open Res
Hlavní autoři: Donovan, Joseph, Phu, Nguyen Hoan, Thao, Le Thi Phuong, Lan, Nguyen Huu, Mai, Nguyen Thi Hoang, Trang, Nguyen Thi Mai, Hiep, Nguyen Thi Thu, Nhu, Tran Bao, Hanh, Bui Thi Bich, Mai, Vu Thi Phuong, Bang, Nguyen Duc, Giang, Do Chau, Ha, Dang Thi Minh, Day, Jeremy, Thuong, Nguyen TT, Vien, Nguyen Nang, Geskus, Ronald B., Hien, Tran Tinh, Kestelyn, Evelyne, Wolbers, Marcel, Chau, Nguyen Van Vinh, Thwaites, Guy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: F1000 Research Limited 2018
Témata:
Study Protocol
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182672/
https://ncbi.nlm.nih.gov/pubmed/30363837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.14007.1
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