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Haplotype analysis suggest that the MLH1 c.2059C > T mutation is a Swedish founder mutation

Lynch syndrome (LS) predisposes to a spectrum of cancers and increases the lifetime risk of developing colorectal- or endometrial cancer to over 50%. Lynch syndrome is dominantly inherited and is caused by defects in DNA mismatch-repair genes MLH1, MSH2, MSH6 or PMS2, with the vast majority detected...

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Bibliografski detalji
Izdano u:Fam Cancer
Glavni autori: von Salomé, Jenny, Liu, Tao, Keihäs, Markku, Morak, Moni, Holinski-Feder, Elke, Berry, Ian R., Moilanen, Jukka S., Baert-Desurmont, Stéphanie, Lindblom, Annika, Lagerstedt-Robinson, Kristina
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182575/
https://ncbi.nlm.nih.gov/pubmed/29288294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0067-x
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