Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding

Joint bleeds are common in congenital hemophilia but rare in acquired hemophilia A (aHA) for reasons unknown. To identify key mechanisms responsible for joint-specific bleeding in congenital hemophilia, bleeding phenotypes after joint injury and tail transection were compared in aHA wild-type (WT) m...

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Pubblicato in:Blood
Autori principali: Wyseure, Tine, Cooke, Esther J., Declerck, Paul J., Behrendt, Niels, Meijers, Joost C. M., von Drygalski, Annette, Mosnier, Laurent O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2018
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182268/
https://ncbi.nlm.nih.gov/pubmed/30026184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-828434
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