Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice

Loss of functional islet β-cell mass through cellular death or dedifferentiation is thought to lead to dysglycemia during the progression from obesity to type 2 diabetes. To assess these processes in a mouse model of obesity, we performed measures of circulating cell-free differentially methylated i...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Tersey, Sarah A., Levasseur, Esther M., Syed, Farooq, Farb, Thomas B., Orr, Kara S., Nelson, Jennifer B., Shaw, Janice L., Bokvist, Krister, Mather, Kieren J., Mirmira, Raghavendra G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181632/
https://ncbi.nlm.nih.gov/pubmed/29812970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800150RR
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