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Recombinant protein susceptibility to proteolysis in the plant cell secretory pathway is pH‐dependent

Cellular engineering approaches have been proposed to mitigate unintended proteolysis in plant protein biofactories, involving the design of protease activity‐depleted environments by gene silencing or in situ inactivation with accessory protease inhibitors. Here, we assessed the impact of influenza...

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Dettagli Bibliografici
Pubblicato in:Plant Biotechnol J
Autori principali: Jutras, Philippe V., Goulet, Marie‐Claire, Lavoie, Pierre‐Olivier, D'Aoust, Marc‐André, Sainsbury, Frank, Michaud, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181212/
https://ncbi.nlm.nih.gov/pubmed/29618167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pbi.12928
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