Integrated proteomic and phosphoproteomic analyses of cisplatin-sensitive and resistant bladder cancer cells reveal CDK2 network as a key therapeutic target

BACKGROUND: Cisplatin-based chemotherapy is currently part of the standard of care for bladder cancer (BC). Unfortunately, some patients respond poorly to chemotherapy and have acquired or developed resistance. The molecular mechanisms underlying this resistance remain unclear. Here, we introduce a...

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Udgivet i:Cancer Lett
Main Authors: Jung, Jae Hun, You, Sungyong, Oh, Jae Won, Yoon, Junhee, Yeon, Austin, Shahid, Muhammad, Cho, Eunho, Sairam, Vikram, Park, Taeeun D., Kim, Kwang Pyo, Kim, Jayoung
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181132/
https://ncbi.nlm.nih.gov/pubmed/30145203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.08.014
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