Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma

BACKGROUND: Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kinase inhibitors (TKIs) in lung cancer have not yet been reported in GBM. CASE...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Loriguet, Lea, Morisse, Mony Chenda, Dremaux, Julie, Collet, Louison, Attencourt, Christophe, Coutte, Alexandre, Boone, Mathieu, Sevestre, Henri, Galmiche, Antoine, Gubler, Brigitte, Chauffert, Bruno, Trudel, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180520/
https://ncbi.nlm.nih.gov/pubmed/30305059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4873-9
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