Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder

Recent results imply that rare variants contribute to the risk of schizophrenia. Exome sequence data from the UK10K project was used to identify three rare, amino acid changing variants in the ITGB4 gene which segregated with schizophrenia in two families: rs750367954, rs147480547 and rs145976111. A...

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Publicado no:Schizophr Res
Main Authors: O'Brien, N.L., Fiorentino, A., Curtis, D., Rayner, C., Petrosellini, C., Al Eissa, M., Bass, N.J., McQuillin, A., Sharp, S.I.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publisher B. V 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179966/
https://ncbi.nlm.nih.gov/pubmed/29526452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2018.03.001
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