Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

Differentiation of astrocytes from human pluripotent stem cells (hPSCs) is a tedious and variable process. This hampers the study of hPSC-generated astrocytes in disease processes and drug development. By using CRISPR/Cas9-mediated inducible expression of NFIA or NFIA plus SOX9 in hPSCs, we develope...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Li, Xiang, Tao, Yezheng, Bradley, Robert, Du, Zhongwei, Tao, Yunlong, Kong, Linghai, Dong, Yi, Jones, Jeffrey, Yan, Yuanwei, Harder, Cole R.K., Friedman, Lindsay Morgan, Bilal, Magd, Hoffmann, Brianna, Zhang, Su-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178885/
https://ncbi.nlm.nih.gov/pubmed/30269954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.019
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