The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

Cyclic β-sheet decapeptides from the tyrocidine group and the homologous gramicidin S were the first commercially used antibiotics, yet it remains unclear exactly how they kill bacteria. We investigated their mode of action using a bacterial cytological profiling approach. Tyrocidines form defined i...

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Pubblicato in:mBio
Autori principali: Wenzel, Michaela, Rautenbach, Marina, Vosloo, J. Arnold, Siersma, Tjalling, Aisenbrey, Christopher H. M., Zaitseva, Ekaterina, Laubscher, Wikus E., van Rensburg, Wilma, Behrends, Jan C., Bechinger, Burkhard, Hamoen, Leendert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178620/
https://ncbi.nlm.nih.gov/pubmed/30301848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00802-18
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