Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

The in vivo niche and basic cellular properties of nephron progenitors are poorly described. Here we studied the cellular organization and function of the MAPK/ERK pathway in nephron progenitors. Live-imaging of ERK activity by a Förster resonance energy transfer biosensor revealed a dynamic activat...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Ihermann-Hella, Anneliis, Hirashima, Tsuyoshi, Kupari, Jussi, Kurtzeborn, Kristen, Li, Hao, Kwon, Hyuk Nam, Cebrian, Cristina, Soofi, Abdul, Dapkunas, Arvydas, Miinalainen, Ilkka, Dressler, Gregory R., Matsuda, Michiyuki, Kuure, Satu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178244/
https://ncbi.nlm.nih.gov/pubmed/30220628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.012
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