Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

The in vivo niche and basic cellular properties of nephron progenitors are poorly described. Here we studied the cellular organization and function of the MAPK/ERK pathway in nephron progenitors. Live-imaging of ERK activity by a Förster resonance energy transfer biosensor revealed a dynamic activat...

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發表在:Stem Cell Reports
Main Authors: Ihermann-Hella, Anneliis, Hirashima, Tsuyoshi, Kupari, Jussi, Kurtzeborn, Kristen, Li, Hao, Kwon, Hyuk Nam, Cebrian, Cristina, Soofi, Abdul, Dapkunas, Arvydas, Miinalainen, Ilkka, Dressler, Gregory R., Matsuda, Michiyuki, Kuure, Satu
格式: Artigo
語言:Inglês
出版: Elsevier 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178244/
https://ncbi.nlm.nih.gov/pubmed/30220628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.012
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