A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment

INTRODUCTION: Accumulation of β-amyloid is a pathological hallmark of Alzheimer's disease (AD). β-Amyloid activates the plasma contact system leading to kallikrein-mediated cleavage of intact high-molecular-weight kininogen (HKi) to cleaved high-molecular-weight kininogen (HKc). Increased HKi c...

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Udgivet i:Alzheimers Dement (Amst)
Main Authors: Yamamoto-Imoto, Hitomi, Zamolodchikov, Daria, Chen, Zu-Lin, Bourne, S. Lloyd, Rizvi, Syeda, Singh, Pradeep, Norris, Erin H., Weis-Garcia, Frances, Strickland, Sidney
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Blood-Based Biomarkers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178129/
https://ncbi.nlm.nih.gov/pubmed/30310850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2018.06.008
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