Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN

Following infection, virulent mycobacteria persist and grow within the macrophage, suggesting that the intrinsic activation of an innate antimicrobial response is subverted by the intracellular pathogen. For Mycobacterium leprae, the intracellular bacterium that causes leprosy, the addition of exoge...

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Detalles Bibliográficos
Publicado en:PLoS Negl Trop Dis
Main Authors: Zavala, Kathryn, Gottlieb, Carter A., Teles, Rosane M., Adams, John S., Hewison, Martin, Modlin, Robert L., Liu, Philip T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177120/
https://ncbi.nlm.nih.gov/pubmed/30300363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006815
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