Idebenone and coenzyme Q(10) are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases

Current peroxisome proliferator-activated receptor (PPAR)-targeted drugs, such as the PPARγ-directed diabetes drug rosiglitazone, are associated with undesirable side effects due to robust agonist activity in non-target tissues. To find new PPAR ligands with fewer toxic effects, we generated transge...

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發表在:Dis Model Mech
Main Authors: Tiefenbach, Jens, Magomedova, Lilia, Liu, Jiabao, Reunov, Arkadiy A., Tsai, Ricky, Eappen, Neena S., Jockusch, Rebecca A., Nislow, Corey, Cummins, Carolyn L., Krause, Henry M.
格式: Artigo
語言:Inglês
出版: The Company of Biologists Ltd 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177011/
https://ncbi.nlm.nih.gov/pubmed/30171034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.034801
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