Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia

Endoglin is a transmembrane glycoprotein expressed in vascular endothelium that plays a key role in angiogenesis. Mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1 (HHT1), characterized by arteriovenous malformations (AVMs) in different organs. These vascular le...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Autores principales: Gallardo-Vara, Eunate, Tual-Chalot, Simon, Botella, Luisa M., Arthur, Helen M., Bernabeu, Carmelo
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176985/
https://ncbi.nlm.nih.gov/pubmed/30108051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.034397
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