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Functional profiling of circulating tumor cells with an integrated vortex capture and single-cell protease activity assay

Tumor cells are hypothesized to use proteolytic enzymes to facilitate invasion. Whether circulating tumor cells (CTCs) secrete these enzymes to aid metastasis is unknown. A quantitative and high-throughput approach to assay CTC secretion is needed to address this question. We developed an integrated...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Dhar, Manjima, Lam, Jeffrey Nam, Walser, Tonya, Dubinett, Steven M., Rettig, Matthew B., Di Carlo, Dino
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176626/
https://ncbi.nlm.nih.gov/pubmed/30224472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803884115
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