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Regulatory γ1 subunits defy symmetry in functional modulation of BK channels

Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa(1.1)) chan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gonzalez-Perez, Vivian, Ben Johny, Manu, Xia, Xiao-Ming, Lingle, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176617/
https://ncbi.nlm.nih.gov/pubmed/30224470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804560115
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