Activation of Serotonin 5-HT(7) Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

We have previously demonstrated that activation of serotonin 5-HT(7) receptors (5-HT(7)R) reverses metabotropic glutamate receptor-mediated long term depression (mGluR-LTD) in the hippocampus of wild-type (WT) and Fmr1 Knockout (KO) mice, a model of Fragile X Syndrome (FXS) in which mGluR-LTD is abn...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Costa, Lara, Sardone, Lara Maria, Bonaccorso, Carmela Maria, D’Antoni, Simona, Spatuzza, Michela, Gulisano, Walter, Tropea, Maria Rosaria, Puzzo, Daniela, Leopoldo, Marcello, Lacivita, Enza, Catania, Maria Vincenza, Ciranna, Lucia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176069/
https://ncbi.nlm.nih.gov/pubmed/30333723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00353
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