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Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway
Mannich bases and its derivatives are regarded as supreme pharmacophores in therapeutics. The study investigates the antimycotic potential of Mannich bases, 1-((1H-benzimidazol-1-yl) methyl) urea (C1) and 1-((3-hydroxynapthalen-2-yl) methyl) thiourea (C2), against Candida albicans. Biofilm and hypha...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175908/ https://ncbi.nlm.nih.gov/pubmed/30297833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32935-9 |
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