Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique

A recombinant produced C-terminus of the C. perfringens enterotoxin (C-CPE) was conjugated to gold nanoparticles (AuNPs) to produce a C-CPE-AuNP complex (C-CPE-AuNP). By binding to claudins, the C- CPE should allow to target the AuNPs onto the claudin expressing tumor cells for a subsequent cell kil...

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Pubblicato in:Sci Rep
Autori principali: Becker, Annegret, Leskau, Miriam, Schlingmann-Molina, Barbara L., Hohmeier, Susanne C., Alnajjar, Suhayla, Murua Escobar, Hugo, Ngezahayo, Anaclet
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175838/
https://ncbi.nlm.nih.gov/pubmed/30297847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33392-0
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