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Dose‐escalation strategies which use subgroup information
Dose‐escalation trials commonly assume a homogeneous trial population to identify a single recommended dose of the experimental treatment for use in future trials. Wrongly assuming a homogeneous population can lead to a diluted treatment effect. Equally, exclusion of a subgroup that could in fact be...
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| Udgivet i: | Pharm Stat |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175353/ https://ncbi.nlm.nih.gov/pubmed/29900666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1860 |
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