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Expansion of the Substrate Specificity of Porcine Kidney D‐Amino Acid Oxidase for S‐Stereoselective Oxidation of 4‐Cl‐Benzhydrylamine

Discovery and development of enzymes for the synthesis of chiral amines have been a hot topic for basic and applied aspects of biocatalysts. Based on our X‐ray crystallographic analyses of porcine kidney D‐amino acid oxidase (pkDAO) and its variants, we rationally designed a new variant that catalyz...

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Detalhes bibliográficos
Publicado no:ChemCatChem
Main Authors: Yasukawa, Kazuyuki, Motojima, Fumihiro, Ono, Atsushi, Asano, Yasuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174955/
https://ncbi.nlm.nih.gov/pubmed/30333894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cctc.201800614
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