Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin

Objective: The mechanisms that lead to endothelial cell (EC) injury and propagate the vasculopathy in Systemic Sclerosis (SSc) are not well understood. Using single cell RNA sequencing (scRNA-seq), our goal was to identify EC markers and signature pathways associated with vascular injury in SSc skin...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Apostolidis, Sokratis A., Stifano, Giuseppina, Tabib, Tracy, Rice, Lisa M., Morse, Christina M., Kahaleh, Bashar, Lafyatis, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174292/
https://ncbi.nlm.nih.gov/pubmed/30327649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02191
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