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Determination of ED50 and time to effectiveness for intrathecal hydromorphone in laboring patients using Dixon’s up-and-down sequential allocation method

BACKGROUND: With the increasing occurrence of drug shortages, understanding the pharmacokinetics of alternative intrathecal opioid administration has gained importance. In particular, additional data are needed to comprehensively evaluate the analgesic properties of intrathecal hydromorphone in the...

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Bibliographic Details
Published in:BMC Anesthesiol
Main Authors: O’Reilly-Shah, Vikas, Lynde, Grant C
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173834/
https://ncbi.nlm.nih.gov/pubmed/30290794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-018-0603-8
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