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A new pharmacokinetic model for (90)Y-ibritumomab tiuxetan based on 3-dimensional dosimetry

Monoclonal antibodies (mAbs) are key components in several therapies for cancer and inflammatory diseases but current knowledge of their clinical pharmacokinetics and distribution in human tissues remains incomplete. Consequently, optimal dosing and scheduling in clinics are affected. With sequentia...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Morschhauser, F., Dekyndt, B., Baillet, C., Barthélémy, C., Malek, E., Fulcrand, J., Bigot, P., Huglo, D., Décaudin, B., Simon, N., Odou, P.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173718/
https://ncbi.nlm.nih.gov/pubmed/30291297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33160-0
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