Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote the current therapeutics remains a large challenge. CRISPR/Cas9, as a gene editing tool, allows for direct ablation of NLRP3 at the genomic level. In this study, we screen an optim...

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Pubblicato in:Nat Commun
Autori principali: Xu, Congfei, Lu, Zidong, Luo, Yingli, Liu, Yang, Cao, Zhiting, Shen, Song, Li, Hongjun, Liu, Jing, Chen, Kaige, Chen, Zhiyao, Yang, Xianzhu, Gu, Zhen, Wang, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173702/
https://ncbi.nlm.nih.gov/pubmed/30291237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06522-5
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