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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

The decline of tissue regenerative potential with age correlates with impaired stem cell function. However, limited strategies are available for therapeutic modulation of stem cell function during aging. Using skeletal muscle stem cells (MuSCs) as a model system, we identify cell death by mitotic ca...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Stem Cell
Prif Awduron: Liu, Ling, Charville, Gregory W., Cheung, Tom H., Yoo, Bryan, Santos, Pauline J., Schroeder, Matthew, Rando, Thomas A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173623/
https://ncbi.nlm.nih.gov/pubmed/30244867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.019
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