The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma

Heparanase (HPSE), a heparan sulfate-specific endo-β-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans. Suramin, a polysulfonated naphthylurea, is an inhibitor of HPSE with suramin analogues. Our objective...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Shah, Shahid, Fourgeaud, Caroline, Derieux, Simon, Mirshahi, Shahsoltan, Contant, Geneviève, Pimpie, Cynthia, Lo Dico, Rea, Soria, Jeannette, Pocard, Marc, Mirshahi, Massoud
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173471/
https://ncbi.nlm.nih.gov/pubmed/30333909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26042
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