The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We found that ccRCC cells are highly sensitive to the dep...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W., Peck, Barrie, Schulze, Almut
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173300/
https://ncbi.nlm.nih.gov/pubmed/29872221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0315-z
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