Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir

HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individual...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: George, Jomy M, Kuriakose, Safia S, Dee, Nicola, Stoll, Pam, Lalani, Tahaniyat, Dewar, Robin, Khan, Muhammad A, Rehman, Muhammad T, Grossman, Zehava, Maldarelli, Frank, Pau, Alice K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172925/
https://ncbi.nlm.nih.gov/pubmed/30568974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy221
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados