Mutation of TP53, translocation analysis and immunohistochemical expression of MYC, BCL-2 and BCL-6 in patients with DLBCL treated with R-CHOP

Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with diverse outcomes. Concurrent translocation of MYC and BCL-2 and/or BCL-6, and concurrent immunohistochemical (IHC) high expression of MYC and BCL-2, have been linked to unfavorable treatment responses. TP53-mutated DLBCL has also b...

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Udgivet i:Sci Rep
Main Authors: Peroja, Pekka, Pedersen, Mette, Mantere, Tuomo, Nørgaard, Peter, Peltonen, Jenni, Haapasaari, Kirsi-Maria, Böhm, Jan, Jantunen, Esa, Turpeenniemi-Hujanen, Taina, Rapakko, Katrin, Karihtala, Peeter, Soini, Ylermi, Vasala, Kaija, Kuittinen, Outi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172218/
https://ncbi.nlm.nih.gov/pubmed/30287880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33230-3
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