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High tension in sarcomeres hinders myocardial relaxation: A computational study

Experiments have shown that the relaxation phase of cardiac sarcomeres during an isometric twitch is prolonged in muscles that reached a higher peak tension. However, the mechanism is not completely understood. We hypothesize that the binding of calcium to troponin is enhanced by the tension in the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dupuis, Lauren J., Lumens, Joost, Arts, Theo, Delhaas, Tammo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171862/
https://ncbi.nlm.nih.gov/pubmed/30286135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204642
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