Tyrosine 450 in the Voltage- and Calcium-Gated Potassium Channel of Large Conductance Channel Pore-Forming (slo1) Subunit Mediates Cholesterol Protection against Alcohol-Induced Constriction of Cerebral Arteries

Alcohol (ethanol) at physiologically relevant concentrations (<100 mM) constricts cerebral arteries via inhibition of voltage- and calcium-gated potassium channels of large conductance (BK) located in vascular smooth muscle (VSM). These channels consist of channel-forming slo1 (cbv1, KCNMA1) and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: North, Kelsey, Bisen, Shivantika, Dopico, Alex M., Bukiya, Anna N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2018
Pynciau:
Cardiovascular
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170972/
https://ncbi.nlm.nih.gov/pubmed/30115756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.250514
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