Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

In order to limit the adverse effects of excessive inflammation, anti-inflammatory responses are stimulated at an early stage of an infection, but during sepsis these can lead to deactivation of immune cells including monocytes. In addition, there is emerging evidence that the up-regulation of mitoc...

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Udgivet i:Front Immunol
Main Authors: Widdrington, John D., Gomez-Duran, Aurora, Pyle, Angela, Ruchaud-Sparagano, Marie-Helene, Scott, Jonathan, Baudouin, Simon V., Rostron, Anthony J., Lovat, Penny E., Chinnery, Patrick F., Simpson, A. John
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170658/
https://ncbi.nlm.nih.gov/pubmed/30319656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02217
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