Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA

To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and cell cycle regulators were observed in p27 (IΔ)...

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Bibliographische Detailangaben
Veröffentlicht in:Lab Anim Res
Hauptverfasser: Choi, Jun Young, Yun, Woo Bin, Kim, Ji Eun, Lee, Mi Rim, Park, Jin Ju, Song, Bo Ram, Kim, Hye Ryeong, Park, Ji Won, Kang, Mi Ju, Kang, Byeong Cheol, Lee, Han-Woong, Hwang, Dae Youn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Association for Laboratory Animal Science 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170220/
https://ncbi.nlm.nih.gov/pubmed/30310408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5625/lar.2018.34.3.118
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