Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors

Cognitive impairment occurs in 40–90% of patients with systemic lupus erythematosus (SLE), which is characterized by autoantibodies to nuclear antigens, especially DNA. We discovered that a subset of anti-DNA antibodies, termed DNRAbs, cross reacts with the N-methyl-d-aspartate receptor (NMDAR) and...

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Udgivet i:J Exp Med
Main Authors: Nestor, Jacquelyn, Arinuma, Yoshiyuki, Huerta, Tomás S., Kowal, Czeslawa, Nasiri, Elham, Kello, Nina, Fujieda, Yuichiro, Bialas, Alison, Hammond, Tim, Sriram, Uma, Stevens, Beth, Huerta, Patricio T., Volpe, Bruce T., Diamond, Betty
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170183/
https://ncbi.nlm.nih.gov/pubmed/30185634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180776
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