Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma

Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would target MYB-driven tumors, we developed a pluripotent zebrafish blastomere culture system. We performed a chemical genetic screen and identifie...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mandelbaum, Joseph, Shestopalov, Ilya A., Henderson, Rachel E., Chau, Nicole G., Knoechel, Birgit, Wick, Michael J., Zon, Leonard I.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170170/
https://ncbi.nlm.nih.gov/pubmed/30209067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180939
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