Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase

Three high-resolution X-ray crystal structures of malate dehydrogenase (MDH; EC 1.1.1.37) from the methylotroph Methylobacterium extorquens AM1 are presented. By comparing the structures of apo MDH, a binary complex of MDH and NAD(+), and a ternary complex of MDH and oxaloacetate with ADP-ribose occ...

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Publicado en:Acta Crystallogr F Struct Biol Commun
Autores principales: González, Javier M., Marti-Arbona, Ricardo, Chen, Julian C.-H., Broom-Peltz, Brian, Unkefer, Clifford J.
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168771/
https://ncbi.nlm.nih.gov/pubmed/30279311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X18011809
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