Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic?

Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C-reactive protein (mCRP). Methods: We used three est...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Slevin, Mark, Iemma, Rocco S., Zeinolabediny, Yasmin, Liu, Donghui, Ferris, Glenn R., Caprio, Vittorio, Phillips, Nicola, Di Napoli, Mario, Guo, Baoqiang, Zeng, Xianwei, AlBaradie, Raid, Binsaleh, Naif K., McDowell, Garry, Fang, Wen-Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168760/
https://ncbi.nlm.nih.gov/pubmed/30319609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02124
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