Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells

In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS). We examined the effect of angiotensin II on ABCA1 expression i...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Lyu, Jingya, Imachi, Hitomi, Fukunaga, Kensaku, Sato, Seisuke, Ibata, Tomohiro, Kobayashi, Toshihiro, Dong, Tao, Yoshimoto, Takuo, Yonezaki, Kazuko, Nagata, Hiromi, Iwama, Hisakazu, Murao, Koji
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168299/
https://ncbi.nlm.nih.gov/pubmed/30108153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M085886
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