White Matter Reference Region in PET Studies of (11)C-Pittsburgh Compound B Uptake: Effects of Age and Amyloid-β Deposition

Amyloid-β (Aβ) deposition as seen on PET using an Aβ-binding agent is a critical diagnostic biomarker for Alzheimer disease (AD). Some reports suggest using white matter (WM) as a reference region for quantification of serial Aβ PET studies; however, nonspecific WM retention in Aβ PET in people with...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Lowe, Val J., Lundt, Emily S., Senjem, Matthew L., Schwarz, Christopher G., Min, Hoon-Ki, Przybelski, Scott A., Kantarci, Kejal, Knopman, David, Petersen, Ronald C., Jack, Clifford R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2018
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167534/
https://ncbi.nlm.nih.gov/pubmed/29674420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.204271
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