Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens

Small-molecule antivirulence agents represent a promising alternative or adjuvant to antibiotics. These compounds disarm pathogens of disease-causing toxins without killing them, thereby diminishing survival pressure to develop resistance. Here we show that the small-molecule antivirulence agents F1...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Greenberg, Michael, Kuo, David, Jankowsky, Eckhard, Long, Lisa, Hager, Chris, Bandi, Kiran, Ma, Danyang, Manoharan, Divya, Shoham, Yaron, Harte, William, Ghannoum, Mahmoud A., Shoham, Menachem
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167350/
https://ncbi.nlm.nih.gov/pubmed/30275455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32829-w
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