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Autonomous conformational regulation of β(3) integrin and the conformation-dependent property of HPA-1a alloantibodies
Integrin α/β heterodimer adopts a compact bent conformation in the resting state, and upon activation undergoes a large-scale conformational rearrangement. During the inside-out activation, signals impinging on the cytoplasmic tail of β subunit induce the α/β separation at the transmembrane and cyto...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166792/ https://ncbi.nlm.nih.gov/pubmed/30209215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806205115 |
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