Integrated pharmacokinetic–pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections

OBJECTIVES: Treatment for nosocomial bloodstream infections (BSI) caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) is challenging. Rising antimicrobial resistance, especially in extended spectrum beta-lactamase production, inadvertently increases empiric carbapenem consumption. Three...

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Detalhes bibliográficos
Publicado no:Infect Drug Resist
Main Authors: Lim, Tze-Peng, Wang, Reyna, Poh, Gang Quan, Koh, Tse-Hsien, Tan, Thean-Yen, Lee, Winnie, Teo, Jocelyn Qi-Min, Cai, Yiying, Tan, Thuan-Tong, Ee, Pui Lai Rachel, Kwa, Andrea L
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166767/
https://ncbi.nlm.nih.gov/pubmed/30310294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S168191
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