Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells

Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype. Here, we demonstrate that the retinal pigment epithelium (RPE), essential for photoreceptor development and functio...

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Publicado no:Cell Rep
Main Authors: May-Simera, Helen Louise, Wan, Qin, Jha, Balendu Shekhar, Hartford, Juliet, Khristov, Vladimir, Dejene, Roba, Chang, Justin, Patnaik, Sarita, Lu, Quanlong, Banerjee, Poulomi, Silver, Jason, Insinna-Kettenhofen, Christine, Patel, Dishita, Lotfi, Mostafa, Malicdan, May, Hotaling, Nathan, Maminishkis, Arvydas, Sridharan, Rupa, Brooks, Brian, Miyagishima, Kiyoharu, Gunay-Aygun, Meral, Pal, Rajarshi, Westlake, Christopher, Miller, Sheldon, Sharma, Ruchi, Bharti, Kapil
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166245/
https://ncbi.nlm.nih.gov/pubmed/29298421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.038
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