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Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites
Transcription factors bind to their binding sites over a wide range of affinities, yet how differences in affinity are encoded in DNA sequences is not well understood. Here, we report X-ray crystal structures of four heterodimers of the Hox protein AbdominalB bound with its cofactor Extradenticle to...
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| 發表在: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166240/ https://ncbi.nlm.nih.gov/pubmed/30157419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.100 |
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