Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue

Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the N-(p-nitrophenyl)acetamide piperinoate (HE-02) was synthesized, and tested for toxicological and antitumor effects...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Santos, Jephesson, Brito, Monalisa, Ferreira, Rafael, Moura, Ana Paula, Sousa, Tatyanna, Batista, Tatianne, Mangueira, Vivianne, Leite, Fagner, Cruz, Ryldene, Vieira, Giciane, Lira, Bruno, Athayde-Filho, Petrônio, Souza, Helivaldo, Costa, Normando, Veras, Robson, Barbosa-Filho, José Maria, Magalhães, Hemerson, Sobral, Marianna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165130/
https://ncbi.nlm.nih.gov/pubmed/30200386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092594
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