Cariprazine, A Dopamine D(2)/D(3) Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer

Multidrug resistance (MDR) is a continuing clinical problem that limits the efficacy of chemotherapy in cancer. The over expression of the ATP-binding cassette (ABC) family G2 (ABCG2) transporter is one of the main mechanisms that mediates MDR in cancer. Molecular modeling data indicated that caripr...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Hussein, Noor, Ashby, Charles R., Amawi, Haneen, Nyinawabera, Angelique, Vij, Atul, Khare, Vishwa M., Karthikeyan, Chandrabose, Tiwari, Amit K.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162716/
https://ncbi.nlm.nih.gov/pubmed/30181510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10090308
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