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Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

A better understanding of mechanistic insights into genes and enzymes implicated in rare diseases provide a unique opportunity for orphan drug development. Advances made in identification of synthetic lethal relationships between rare disorder genes with oncogenes and tumor suppressor genes have bro...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Bhattacharjee, Sonali, Nandi, Saikat
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162646/
https://ncbi.nlm.nih.gov/pubmed/30200453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10090298
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